Ion Chromatography Standards
Apexbio Technology LLC Diethylstilbestrol 56-53-1 1g
Diethylstilbestrol (56-53-1) is a small-molecule inhibitor targeting 11 -hydroxysteroid dehydrogenase type 2 (HSD11B2) and interacting with estrogen receptors It is designed to modulate hormonal signaling and cellular steroid metabolism thereby regulating processes such as apoptosis and autophagy Diethylstilbestrol exerts its biological activity primarily through the inhibition of HSD11B2 and modulation of estrogen receptor-mediated signaling In cell-based studies Diethylstilbestrol induces oxidative DNA damage and triggers apoptotic responses in spermatogonial stem cells as well as promotes autophagy in thymic cells Based on these pharmacological properties Diethylstilbestrol holds research potential in exploring estrogen receptor-mediated signaling hormone-regulated molecular events apoptosis pathways and autophagy mechanisms in vitro
Apexbio Technology LLC PDE5-IN-7 139756-21-1 1g
PDE5-IN-7 (CAS 139756-21-1) is a selective inhibitor of phosphodiesterase 5 (PDE5) functioning by impeding PDE5 enzymatic activity and thereby reducing the hydrolysis of cyclic guanosine monophosphate (cGMP) This results in elevated intracellular cGMP levels In biochemical assays PDE5-IN-7 demonstrates potent inhibition of PDE5 with an IC50 of approximately 5 nM while displaying significantly lower potency against PDE1 (IC50 300 nM) Due to its selectivity and potency PDE5-IN-7 is valuable for investigating cGMP-mediated signaling vasorelaxation mechanisms and pathways involved in cardiovascular physiology
Apexbio Technology LLC Casanthranol 8024-48-4 1g
Casanthranol is a natural mixture of anthranol glycosides derived from the bark of Rhamnus purshiana commonly known as cascara sagrada Casanthranol exerts its biological activity primarily through intestinal bacterial hydrolysis releasing anthraquinone aglycones that interact with colonic mucosa to enhance bowel motility and stimulate fluid accumulation in the intestinal lumen Based on these pharmacological properties casanthranol holds research potential in studies of intestinal motility investigation of laxative mechanisms microbiota-mediated glycoside metabolism and as a chemical probe for elucidating gastrointestinal physiology and anthraquinone glycoside bioactivity
Apexbio Technology LLC Sudan I 842-07-9 1g
Sudan I (842-07-9) is a small-molecule inhibitor targeting microbial growth notably Clostridium perfringens and Clostridium ramosum It is used to modulate bacterial physiology by altering signaling pathways involved in cell viability and replication Sudan I exerts its biological activity primarily through disruption of cellular metabolic processes essential for microbial proliferation In in vitro studies Sudan I demonstrates inhibitory activity with IC50 values typically between 10 30 M depending on the bacterial strain and experimental conditions Based on these pharmacological properties Sudan I holds research potential in microbiology investigation and antimicrobial assay development particularly for studies on microbial inhibition mechanisms and comparative efficacy testing
Apexbio Technology LLC Nafcillin Sodium 7177-50-6 1g
Nafcillin Sodium (7177-50-6) is a small-molecule inhibitor targeting -lactamase It is designed to reversibly inhibit -lactamase thereby preventing bacterial resistance mediated by hydrolysis of -lactam antibiotics Nafcillin Sodium exerts its biological activity primarily through reversible inhibition of -lactamase In in vitro studies Nafcillin Sodium demonstrates inhibitory activity with an IC50 value of approximately 33 mM Based on these pharmacological properties Nafcillin Sodium holds research potential in investigating -lactamase-mediated antibiotic resistance mechanisms evaluating therapeutic combination strategies and studying bacterial susceptibility profiles
Apexbio Technology LLC Lansoprazole 103577-45-3 1g
Lansoprazole (103577-45-3) is a small-molecule inhibitor targeting gastric H K -ATPase an enzyme responsible for gastric acid secretion via proton pump activity It is designed to inhibit H K -ATPase activity thereby suppressing gastric acid production Lansoprazole exerts its biological activity primarily through selective inhibition of the H K -ATPase enzyme In experimental models lansoprazole demonstrates inhibitory activity with an IC50 value of approximately 6 3 M for enzyme activity and 0 09 M for suppression of histamine-stimulated gastric acid secretion Based on these pharmacological properties lansoprazole holds research potential in studies of gastric acid-related pathophysiology gastroprotective mechanisms and ulcer formation processes
Apexbio Technology LLC AOA hemihydrochloride 2921-14-4 1g
Aminooxyacetic acid hemihydrochloride (AOA hemihydrochloride CAS 2921-14-4) is a biochemical modulator that inhibits the malate-aspartate shuttle thereby disrupting the transfer of NADH between mitochondria and the cytosol Additionally AOA suppresses -aminobutyric acid transaminase (GABA-T) leading to reduced degradation of -aminobutyric acid (GABA) This compound is widely utilized in studies of cellular energy metabolism bioenergetic processes and mechanistic investigations of GABA-related metabolic pathways in the nervous system
Apexbio Technology LLC Ethionamide 536-33-4 1g
Ethionamide (CAS 536-33-4) is a small-molecule inhibitor targeting enoyl-acyl carrier protein reductase (InhA) It is designed to inhibit mycolic acid biosynthesis thereby disrupting bacterial cell-wall integrity Ethionamide exerts its biological activity primarily through inhibiting the function of InhA In in vitro studies Ethionamide demonstrates antimycobacterial activity against Mycobacterium tuberculosis with reported MIC values typically ranging from approximately 0 3 to 2 5 g/mL Based on these pharmacological properties Ethionamide holds research potential in studies of multidrug- or extensively drug-resistant tuberculosis
Apexbio Technology LLC Pyriproxyfen 95737-68-1 1g
Pyriproxyfen (CAS 95737-68-1) is a small-molecule inhibitor targeting insect juvenile hormone receptors It is designed to interfere with hormone-mediated developmental signaling thereby disrupting endocrine-regulated metamorphosis in insect larvae Pyriproxyfen exerts its biological activity primarily through binding to juvenile hormone receptors impeding physiological maturation and reproduction cycles in target arthropod populations In laboratory experiments pyriproxyfen demonstrates inhibitory activity with IC50 values ranging from approximately 0 1 to 10 M depending on insect species and experimental conditions Based on these pharmacological properties pyriproxyfen holds research potential in agricultural pest management and public health applications involving vector-borne diseases transmitted by arthropods
SPEX CERTIPREP LLC 3P BROMIDE STD 1000PPM 250ML
(HPS by Zeptometrix) 1000 ug/mL Bromide in H2O; Single Component IC standard, 18 Month Expiry Date. Prepared from high-purity salts in 18-megaohm water, packaged in HDPE bottles.
Apexbio Technology LLC IBC 293 306935-41-1 1g
IBC 293 (CAS 306935-41-1) is a selective agonist of the G protein-coupled receptor GPR109b By activating GPR109b IBC 293 modulates specific signaling pathways involved in the regulation of lipid and glucose metabolism The compound exhibits high affinity for the human GPR109b receptor with a reported pEC50 of approximately 6 4 IBC 293 serves as a valuable research tool for elucidating GPR109b-mediated mechanisms and receptor function in the context of metabolic syndrome and cardiovascular disease models
Apexbio Technology LLC L-Thyroxine 51-48-9 1g
L-Thyroxine (51-48-9) is a thyroid hormone analog that regulates cellular metabolism via thyroid hormone receptor activation It modulates gene expression after peripheral conversion to its active form triiodothyronine (T3) thereby influencing metabolic pathways including lipid catabolism and cholesterol metabolism L-Thyroxine exerts its biological activity primarily through receptor-mediated transcriptional regulation Based on these pharmacological properties L-Thyroxine holds research potential in thyroid function studies and metabolic regulation investigations particularly in the context of hypothyroidism and altered thyroid hormone signaling
Apexbio Technology LLC Trichlormethiazide 133-67-5 1g
Trichlormethiazide is a small-molecule inhibitor targeting the sodium-chloride cotransporter (NCC) It is designed to inhibit NCC in the distal convoluted tubules thereby decreasing sodium and chloride reabsorption and modulating fluid and electrolyte balance Trichlormethiazide exerts its biological activity primarily through inhibition of sodium and chloride reabsorption Based on these pharmacological properties Trichlormethiazide holds research potential in studies of electrolyte and fluid regulation hypertension-related pathophysiology and renal function as well as the investigation of renal tubular sodium handling and screening interventions affecting nephron sodium transport processes in biological models
Apexbio Technology LLC Tolnaftate 2398-96-1 1g
Tolnaftate (2398-96-1) is a small-molecule inhibitor targeting fungal squalene epoxidase It is designed to block this key enzyme thereby disrupting ergosterol biosynthesis within fungal cell membranes and inhibiting fungal proliferation Tolnaftate exerts its biological activity primarily through inhibition of squalene epoxidase In in vitro studies Tolnaftate demonstrates antifungal inhibition with an IC50 value typically between 0 01 to 2 g/mL depending on fungal strain Based on these pharmacological properties Tolnaftate holds research potential in evaluating drug sensitivity profiles investigating fungal resistance mechanisms and validating antifungal drug targets